Πιέτα Αντιγόνη

MD, MSc

Rheumatologist

Λίγα λόγια για εμένα

My name is Antigone Pieta, I am a Rheumatologist and I run a Rheumatology practice in the center of Preveza. I hold a Medical degree from the University of Ioannina and a postgraduate degree in "Rheumatology-Musculoskeletal Health" from the National and Kapodistrian University of Athens.

I have been trained in various hospitals in Greece (General Panarcadic Hospital of Tripoli, "Tzaneio" General Hospital of Piraeus, "Attikon" University General Hospital, University General Hospital of Ioannina), but occasionally in clinics abroad ("Yeditepe" University Hospital of Istanbul, Lambeth Walk GP of London).

My research interests focus on systemic lupus erythematosus, treatment response and disease activity measurements in systemic autoimmune diseases. My work so far includes organizing a research biobank and conducting randomized clinical trials in rheumatic diseases.

From 2020 to 2023 I served as a member of the European Group of Young Rheumatologists EMEUNET with the aim of addressing the educational needs and promoting the research interests of aspiring young academic Rheumatologists.

Εκπαίδευση

2024

2017-2019

2008-2014

Specialty title Rheumatology

Postgraduate Program in “Rheumatology-Musculoskeletal”
Health",
National and Kapodistrian University of Athens
Diploma thesis: "Response of patients with Systemic
Lupus erythematosus of moderate and severe severity in treatment:
rates of achieving low activity and remission"
Degree grade: 9.7 "Excellent"

Department of Medicine, School of Health Sciences
University of Ioannina
Degree grade: 7.18 "Very good"

Professional experience

2018-present

2020-2024

2018-2022

2016-2018

2015-2016

Scientific Associate of the Laboratory of Autoimmunity and Inflammation, Biomedical Research Foundation of the Academy of Athens
(Scientific Supervisor: Prof. Boubas Dimitrios)

Participation in the Horizon 2020 program

Resident Rheumatologist, Rheumatology Clinic, University General Hospital of Ioannina (Director: Prof. Voulgari Paraskevi)

Clinical Trials Investigator (TREAT-RA, ASSURE)

Scientific Associate, Rheumatology-Clinical Immunology Unit, 4th Department of Pathology, "Attikon" University General Hospital (Director: Prof. Boumpas Dimitrios)

Clinical Trial Investigator (MAXIMISE, SELECT-PsA1, SERENA, BENEFICIAL, NCT02770170, NCT03385564, NCT02373813)
Biobank Manager for patients with autoimmune diseases

Resident in Internal Medicine, 3rd Internal Medicine Clinic, Piraeus General Hospital "Tzaneio"

(Director: Dr. Voutsinas Dionysios)

Obligatory Doctor of the Field Service of the Stemnitsa Regional Hospital

K.Y. Dimitsanas, General Panarcadic Hospital of Tripoli

Training in musculoskeletal ultrasound

International Musculoskeletal Ultrasound Course (MITOS)
- basic level (2019)

- intermediate level (2022)

Daily practice during the specialty at the University General Hospital of Ioannina and "Attikon" University General Hospital.

Publications

Pieta A , Nikolopoulos D, and Fanouriakis A.

"Neuropsychiatric systemic lupus erythematosus: Issues in diagnosis and management" Medicine Matters rheumatology. Editorial in Online Journal (2019)

Nikolopoulos D, Kostopoulou M, Pieta A , Karageorgas T, Tseronis D, Chavatza K, Flouda S, Rapsomaniki P, Banos A, Kremasmenou E, Tzavara V, Katsimbri P, Fanouriakis A, Boumpas DT.

Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the 'Attikon' cohort. Lupus. 2020;29(5):514-522.
doi:10.1177/0961203320908932

Nikolopoulos DS, Kostopoulou M, Pieta A , Flouda S, Chavatza K, Banos A, Boletis J, Katsimbri P, Boumpas DT, Fanouriakis A.

Transition to severe phenotype in systemic lupus erythematosus initially presenting with non-severe disease: implications for the management of early disease. Lupus Sci Med. 2020? 7(1):e000394.
doi:10.1136/lupus-2020-000394

Grigoriou M, Banos A, Filia A, Pavlidis P, Giannouli S, Karali V, Nikolopoulos D, Pieta A , Bertsias G, Verginis P, Mitroulis I, Boumpas DT.
Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus. Ann Rheum Dis. 2020? 79(2):242-253.

doi:10.1136/annrheumdis-2019-215782

Karampeli M, Konstantinos T, Flouda S, Chavatza A, Nikolopoulos D, Pieta A , Tseronis D, Aggelakos M, Kassara D, Tzavara V, Katsimbri P, Boumpas D, Karageorgas T.

Interstitial Pneumonia with Autoimmune Features (IPAF): A Single-Centre, Prospective Study. Meditr J Rheumatol. 2020? 31(3):330-336. Published 2020 Sep 30.

doi:10.31138/mjr.31.3.330

Banos A, Thomas K, Garantziotis P, Malissovas N, Filia A, Pieta A , Nikolopoulos D, Moustafa S, Panagiotopoulos A, Boumpas DT, Vassilopoulos D.

Mitophagy Balance in Various Cell Subsets in Patients with ANCA-Associated Vasculitis and Correlation with the Presence of Anti-Neutrophil Cytoplasmic Antibodies. Meditr J Rheumatol. 2020 Jul 4;31(3):366-368.

doi: 10.31138/mjr.31.3.366. PMID: 33163873; PMCID: PMC7641023.

Pieta A , Pelechas E, Gerolymatou N, Voulgari PV, Drosos AA.

Calcified constrictive pericarditis resulting in tamponade in a patient with systemic lupus erythematosus. Rheumatol Int. 2020? 10.1007/s00296-020-04747-6.

doi:10.1007/s00296-020-04747-6

Pieta A , Zioga A, Skalkou A, Venetsanopoulou AI, Drosos AA, Voulgari PV.
Fibroblastic rheumatism: an uncommon arthritis. A case-based review. Rheumatol Int. 2021? 10.1007/s00296-021-05004-0.
doi:10.1007/s00296-021-05004-0

Nikolopoulos D, Kitsos D, Papathanasiou M, Chondrogianni M, Theodorou A, Garantziotis P, Pieta A , Doskas T, Bertsias G, Voumvourakis K, Boumpas DT, Fanouriakis A.

Demyelination with autoimmune features: a distinct clinical entity? Results from a longitudinal cohort. Rheumatology (Oxford). 2021 Sep 1;60(9):4166-4174.

doi: 10.1093/rheumatology/keaa902. PMID: 33404657.

Voulgari PV, Venetsanopoulou AI, Pieta A , Tziortzioti Z, Zikou AK, Drosos AA.

Orbital myositis in systemic lupus erythematosus: a case-based review. Rheumatol Int. 2022? 42(8):1453-1460.
doi:10.1007/s00296-022-05114-3

Nikolopoulos D, Kitsos D, Papathanasiou M, Kapsala N, Garantziotis P, Pieta A , Gioti O, Grivas A, Voumvourakis K, Boumpas D, Fanouriakis A.
Demyelinating Syndromes in Systemic Lupus Erythematosus: Data From the "Attikon" Lupus Cohort. Front Neurol. 2022;13:889613.
doi:10.3389/fneur.2022.889613

Frangou E, Garantziotis P, Grigoriou M, Banos A, Nikolopoulos D, Pieta A , Doumas SA, Fanouriakis A, Hatzioannou A, Manolakou T, Alissafi T, Verginis P, Athanasiadis E, Dermitzakis E, Bertsias G, Filia A, Boumpas DT.

Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis. Ann Rheum Dis. 2022;81(10):1409-1419.

doi:10.1136/annrheumdis-2021-222069

Pieta A , Venetsanopoulou AI, Kittas C, Christaki E, Voulgari PV.

Recurrent Scedosporium apiospermum Cutaneous Infection in a Patient with Rheumatoid Arthritis: The Potent Role of IL-6 Signaling Pathway Blockade: A Case-Based Review.

J Fungi (Basel). 2023 Jun 18;9(6):683.
doi: 10.3390/jof9060683. PMID: 37367619; PMCID: PMC10304890.

Nikolopoulos D, Loukogiannaki C, Sentis G, Garantziotis P, Manolakou T, Kapsala N, Nikoloudaki M, Pieta A , Flouda S, Parodis I, Bertsias G, Fanouriakis A, Filia A, Boumpas DT.

Disentangling the riddle of systemic lupus erythematosus with antiphospholipid syndrome: blood transcriptome analysis reveals a less-pronounced IFN-signature and distinct molecular profiles in venous versus arterial events. Ann Rheum Dis. 2024 Apr 12:ard-2024-225664.

doi: 10.1136/ard-2024-225664. PMID: 38609158.

Pappa M, Kosmetatou M, Pieta A , Nikoloudaki M, Liapis NM, Tsalapaki C, Chalkia A, Argyriou E, Dimitroulas T, Cheila M, Demirtzoglou G, Papagoras C, Goules A, Katsiari C, Vassilopoulos D, Sidiropoulos P, Boki KA, Sfikakis PP, Liapis G, Gakiopoulou H, Voulgari PV, Boumpas DT, Bertsias G, Tektonidou MG, Fanouriakis A.

Attainment of EULAR/ERA-EDTA targets of therapy with current immunosuppressive regimens and adjustments in treatment: a multicentre, real-life observational study. RMD Open. 2024 Sep 18;10(3):e004437. doi: 10.1136/rmdopen-2024-004437. PMID: 39299738; PMCID: PMC11429000.

Garantziotis P, Moysidou GS, Kapsala N, Flouda S, Nikolopoulos D, Chavatza K, Sentis G, Filia A, Malissovas N, Pieta A , Banos A, Katechis S, Fanouriakis A, Bertsias G, Boumpas DT. Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus. RMD Open. 2025 Mar 12;11(1):e005050. doi: 10.1136/rmdopen-2024-005050. PMID: 40081913; PMCID: PMC11931925.

Nikolopoulos D, Sentis G, Kitsios I, Garantziotis P, Kapsala N, Pieta A , Flouda S, Manolakou T, Nikoloudaki M, Banos A, Chavatza K, Parodis I, Filia A, Bertsias G, Fanouriakis A, Boumpas DT. Enhanced B cell and complement cascade gene signatures in patients with neuropsychiatric systemic lupus erythematosus. Ann Rheum Dis. 2025 May 9:S0003-4967(25)00893-3. doi: 10.1016/j.ard.2025.04.006. Epub ahead of print. PMID: 40348638.

Pappa M, Flouda S, Pieta A , Katechis S, Nikoloudaki M, Liapis NM, Tsalapaki C, Chalkia A, Argyriou E, Dimitroulas T, Cheila M, Papagoras C, Goules AV, Katsiari C, Vassilopoulos D, Sidiropoulos P, Boki KA, Sfikakis PP, Liapis G, Gakiopoulou C, Karasavvidou F, Voulgari PV, Boumpas D, Bertsias GK, Tektonidou MG, Fanouriakis A. Comparable 12-month renal response outcomes with medium vs. high-dose starting prednisone in a real-world study of lupus nephritis, Rheumatology, 2025; keaf574, https://doi.org/10.1093/rheumatology/keaf574

Participation in international conferences

Nikolopoulos D, Sentis G, Kitsos J, Garantziotis P, Kapsala N, Pieta A, Nikoloudaki M, Manolakou T, Flouda S, Parodis I, Filia A, Bertsias G, Fanouriakis A and Boumpas D.

Blood Transcriptome Analysis Reveals Enhanced B Cell and Complement Cascade Signatures in Patients with Major Neuropsychiatric Systemic Lupus Erythematosus

Poster presented at: ACR 2024, Washington, USA

Nikolopoulos D, Loukogiannaki C, Sentis G, Garantziotis P, Manolakou T, Kapsala N, Nikoloudaki M, Pieta A, Flouda S, Parodis I, Bertsias GK, Fanouriakis A, Filia A, Boumpas D.

The molecular landscape of antiphospholipid syndrome in systemic lupus erythematosus: distinct transcriptional profiles in venous versus arterial events, with potential therapeutic implications.

Oral abstract presented at: EULAR 2024, Vienna, Austria

Venetsanopoulou AI, Pieta A, Koletsos N, Karakosta M, Tziortzioti Z , Voulgari PV.

Prophylactic Efficacy of Tixagevimab-Cilgavimab in Rituximab-Treated Patients with Autoimmune Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2024-eular.4742

Publication Only at: EULAR 2024, Vienna, Austria

Pappa M, Kosmetatou M, Pieta A, Nikoloudaki M, Argyriou E, Tsalapaki C, Chalkia A, Dimitroulas T, Cheila M, Papagoras C, Goules A, Petras D, Vassilopoulos D, Boki KA, Sfikakis P, Voulgari P, Bertsias G, Boumpas D, Tektonidou M, Fanouriakis A.

Attainment of EULAR/ERA-EDTA Treatment targets in the first year in lupus nephritis: a multicenter observational study. Annals of the Rheumatic Diseases 2023;82:907.

Poster presented at: EULAR 2023, Milan, Italy

Markousis-Mavrogenis G, Venetsanopoulou AI, Pieta A, Ntalas I, Naka C, Pagounis I, Toliopoulos D, Mouka G, Voulgari P, Mavrogeni SI.

Combined brain/heart magnetic resonance imaging reveals subclinical brain lesions in patients with inflammatory arthritides and cardiac symptoms. Annals of the Rheumatic Diseases 2023;82:775.

Poster presented at: EULAR 2023, Milan, Italy

Invited Chair, Imaging in Rheumatic Diseases: don’t miss diagnoses and common pitfalls in daily practice

EMEUNET session presented at: EULAR 2022, Copenhagen, Denmark

Nikolopoulos D, Kitsos D, Papathanasiou M, Kapsala N, Grivas A, Gioti O, Garantziotis P, Pieta A, Voumvourakis K, Boumpas D, Fanouriakis A.

Central Nervous System Demyelinating Syndromes in Systemic Lupus Erythematosus: Results from “Attikon” Lupus Cohort. Annals of the Rheumatic Diseases 2022;81:287.

Poster presented at: EULAR 2022, Copenhagen, Denmark

Invited Chair, «Multi-disciplinary patient care: the new era of Rheumatology»

EMEUNET session presented at: EULAR 2021, E-Congress

Kapsala N, Nikolopoulos D, Flouda S, Chavatza K, Pieta A, Grivas A, Ntourou A, Togia K, Rapsomaniki P, Gerogianni T, Tseronis D, Aggelakos M, Karageorgas T, Katsimpri P, Bertsias G, Fanouriakis A, Boumpas D.

Systemic Lupus Erythematosus (SLE) diagnosed during hospitalization: clinical phenotype and performance of the SLE risk probability index (SLERPI). Annals of the Rheumatic Diseases 2021;80:631.

ePoster presented at: EULAR 2021, E-Congress

Chavatza K, Kostopoulou M, Nikolopoulos D, Gioti O, Togia K, Flouda S, Kapsala N, Kosmetatou M, Moysidou G, Grivas A, Pieta A, Ntourou A, Rapsomaniki P, Gerogianni T, Tseronis D, Aggelakos M, Karageorgas T, Katsimpri P, Andreoli L, Aringer M, Boletis J, Doria A, Houssiau F, Jayne D, Mosca M, Svenungsson E, Tincani A, Bertsias G, Fanouriakis A, Boumpas D.

EULAR Recommendation-based Quality Indicators (QIS) for Systemic Lupus Erythematosus (SLE): elaboration, final set, performance and initial validation. Annals of the Rheumatic Diseases 2021;80:635-636.

ePoster presented at: EULAR 2021, E-Congress

Kapsala N, Flouda S, Nikolopoulos D, Chavatza K, Pieta A, Grivas A, Ntourou A, Togia K, Rapsomaniki P, Gerogianni T, Tseronis D, Aggelakos M, Karageorgas T, Katsimpri P, Bertsias G, Fanouriakis A, Boumpas D.

The journey of patients from first symptoms to diagnosis of Systemic Lupus Erythematosus (SLE): an observational study. Annals of the Rheumatic Diseases 2021;80:632-633.

ePoster presented at: EULAR 2021, E-Congress

Havatza K, Togia K, Flouda S, Pieta A, Gioti O, Nikolopoulos D, Kapsala N, Ntourou A, Rapsomaniki P, Gerogianni T, Tseronis D, Aggelakos M, Karageorgas T, Katsimpri P, Bertsias G, Thomas K, Boumpas D, Fanouriakis A.

Therapeutic Τargets and Quality Indicators in Systemic Lupus Erythematosus (SLE), defined according to the 2019 update of the EULAR recommendations: Data from the “Attikon“ lupus cohort. Annals of the Rheumatic Diseases 2020;79:669-670.

ePoster presented at: EULAR 2020, E-Congress

Adamichou C, Nikolopoulos D, Nikoloudaki M, Rahme Z, Fredi M, Pieta A, Repa A, Parma A, Kalogiannaki E, Avgustidis N, Kougkas N, Banos A, Eskitzis A, Bortoluzzi A, Jacobsen S, Sidiropoulos P, Dermitzakis E, Mosca M, Inês L, Andreoli L, Tincani A, Fanouriakis A, Bertsias G.

Α multicenter “at-risk” cohort for the discovery of environmental, clinical and molecular predictors for the transition into systemic lupus erythematosus (SLE). Annals of the Rheumatic Diseases 2020;79:661.

ePoster presented at: EULAR 2020, E-Congress

Manolakou T, Banos A, Filia A, Pieta A, Verginis P and Boumpas D. Aberrant DNA damage response of B cell populations in systemic lupus erythematosus. Lupus Science & Medicine 2020;7:doi: 10.1136/lupus-2020-eurolupus.147.

ePoster presented at: 12th European Lupus eMeeting (2020)

Nikolopoulos D, Pieta A, Kostopoulou M, Erden A, Katsimbri P, Boumpas D, Fanouriakis A. Trends of severity, progression and burden of disease in the “Attikon” Systemic Lupus Erythematosus (SLE) cohort: evidence for the rule of “one third” in disease severity. Annals of the Rheumatic Diseases 2019;78:405.

Poster presented at: EULAR 2019, Madrid, Spain

Banos A, Grigoriou M, Filia A, Pavlidis P, Giannouli L, Karali V, Nikolopoulos D, Pieta A, Mitroulis I, Verginis P, Boumpas D. The hematopoietic stem cells (HSCS) in Systemic Lupus Erythematosus (SLE) reprogram their transcriptome: implications for the pathogenesis of the disease. Annals of the Rheumatic Diseases 2019;78:381.

Poster presented at: EULAR 2019, Madrid, Spain

Pieta A, Dimoliatis IDK, Peroulis M, Arnaoutoglou E, Avgos S, Matsagkas M. Development and initial use of the self-accomplished, self-assessment tool iCAN!-Angio specially designed for medical students studied the selected component ‘Angiology- Vascular Surgery'. Abstract book 2013:336–337

Poster presented at: AMEE 2013, Prague, Czech Republic